Adjust oven racks to upper and lower-middle positions. Place a 12-inch oven-safe skillet on the upper rack. Line a rimmed baking sheet with aluminum foil for easy cleanup and place on lower rack. Preheat the oven to 425 degrees.
Transfer cherries to a medium bowl and add lemon juice. Toss well.
Meanwhile, in a small bowl, combine 2 teaspoons flour and cinnamon. Sprinkle over cherries and toss to coat.
In a large bowl, whisk together eggs, 2/3 cup sugar, vanilla, and salt until pale and smooth, about 1 minute. Whisk in remaining 1/2 cup flour until smooth. Whisk in milk and cream until combined.
Carefully remove skillet from oven (handle will be very hot) and set on wire rack. Add butter and swirl to coat bottom and sides of skillet (butter will melt and brown quickly).
Immediately pour batter into skillet and arrange cherries evenly on top (it's okay if some sink into the batter). Transfer skillet to upper rack.
Bake until puffy and golden brown, about 18 to 22 minutes, rotating skillet halfway through baking time. The center of the clafouti should reach 195 degrees on an instant-read thermometer and the edges will be dark brown.
Transfer to wire rack and cool 25 minutes. Dust with powdered sugar. Slice into wedges to serve.